Skip to main content Skip to main navigation menu Skip to site footer
Published: 2020-05-20

PTSD is associated with structural changes in the neural connections between the right and left hippocampus

Bogomolets National Medical University
PTSD Neuroimaging


A multi-cohort analysis of the diffusion magnetic resonance imaging (dMRT) results of 3047 people from 28 cohorts, conducted by a large group of researchers from 92 scientific institutions found that PTSD is associated with structural changes in the tapetum, connecting the right and left hippocampus. These changes may explain the hippocampal dysfunction associated with behavioral and cognitive symptoms of PTSD.

Full-text of the article is available for this locale: Українська.


  1. Uno H, Eisele S, Sakai A, Shelton S, Baker E, DeJesus O, et al. Neurotoxicity of glucocorticoids in the primate brain. Horm Behav. 1994;28:336–48.
  2. Basser PJ, Mattiello J, LeBihan D. MR diffusion tensor spectroscopy and imaging. Biophys J. 1994;66:259–67.
  3. Dennis EL, Disner SG, Fani N, et al. Altered white matter microstructural organization in posttraumatic stress disorder across 3047 adults: results from the PGC-ENIGMA PTSD consortium [published online ahead of print, 2019 Dec 19]. Mol Psychiatry. 2019;10.1038/s41380-019-0631-x. doi:10.1038/s41380-019-0631-x